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These effects, along with a earlier report showing that a small-molecule ACKR3 agonist CCX771 reveals anxiolytic-like actions in mice,2 support the notion of focusing on ACKR3 as a novel technique to modulate the opioid system, which could open new therapeutic avenues for opioid-related Conditions.Tabernaemontana divaricata Conolidine is an indole